Botulinum neurotoxin injections were first used medically by Neurologists to treat spastic muscle disorders, such as blepharospasms and hemifacial spasms. But its usefulness in relaxing hyperactive muscles soon led to aesthetic uses pioneered, developed, and mastered by Dermatologic surgeons, mainly to treat glabellar frown lines as its initially FDA-approved indication, followed by off-label uses to reduce horizontal forehead worry lines and relax periorbital smile lines (crow’s feet). Other important popular indications for treatment with botulinum toxin include treatment of axillary, palmar, and plantar hyperhidrosis; face and body shaping by injections to the masseter, trapezius, or calf muscles; non-surgical facelift using micro toxin technique; neck rejuvenation by Nefertiti lift and platysma injections. Newer indications are constantly being discovered. Patients with known neuromuscular diseases, such as Eaton-Lambert Disease, are not eligible for treatment. Otherwise, Botulinum neurotoxin treatment is a popular quick fix for patients who want to look 20 years younger in the quickest way (results are evident in as early as 3 days post-injection) and shortest amount of downtime (patients can resume their usual activities or go back to work immediately after treatment). The only drawback for patients is that results are not permanent and they have to come back every 4months for repeat injections to maintain correction. But this temporary nature of the treatment has important advantages: First, if the patient does not like the result, he doesn’t have to live with it forever because it will wear off in four months. Second, Patients’ features change with age and being temporary, the doctor can modify the doses and injection points as needed by the patient. The prerequisites of all physician injectors are a mastery of the anatomy of the areas to be treated and a sound knowledge, training, and experience in injection techniques.